2026 年 8 月 26 日:美国 FDA 批准 daraxonrasib(RASONQUE)用于转移性胰腺腺癌,成为首个获批的 RAS 靶向胰腺癌治疗药物。 查看全部动态 →

参考资料

监管文件、同行评审文献、试验注册信息与官方资源

监管文件

  1. FDA approves daraxonrasib for metastatic pancreatic adenocarcinoma
    U.S. Food and Drug Administration. FDA 药品批准公告, 2026

文献

  1. Daraxonrasib versus chemotherapy in previously treated metastatic pancreatic cancer (RASolute 302)
    O'Reilly EM, Wolpin BM, et al.. New England Journal of Medicine, 2026
  2. Daraxonrasib in previously treated RAS-mutant non-small-cell lung cancer: phase 1/2 results
    Hong DS, et al.. New England Journal of Medicine, 2026

试验注册

  1. RASolute 302: Phase 3 study of daraxonrasib vs. standard of care chemotherapy in previously treated metastatic PDAC
    ClinicalTrials.gov. NCT06625320, 2024
  2. RASolve 301: Study of daraxonrasib in patients with RAS mutated NSCLC
    ClinicalTrials.gov. NCT06881784, 2025
  3. RMC-6236-001: First-in-human study of RMC-6236 in RAS-mutant solid tumors
    ClinicalTrials.gov. NCT05379985, 2022

官方网站

  1. Revolution Medicines 官方网站
    Revolution Medicines, Inc.. 公司官网
  2. Revolution Medicines 临床试验查询
    Revolution Medicines, Inc.. 临床试验信息

新闻

  1. Daraxonrasib Demonstrates Unprecedented Overall Survival Benefit in Pivotal Phase 3 RASolute 302 Clinical Trial
    Revolution Medicines. 公司新闻稿, 2026
  2. Revolution Medicines Announces FDA Breakthrough Therapy Designation for Daraxonrasib
    Revolution Medicines. 公司新闻稿, 2025
  3. Daraxonrasib Nearly Doubles Survival in Previously Treated Metastatic Pancreatic Cancer
    The ASCO Post. ASCO 2026 会议报道, 2026
本站内容仅供医学专业人士及公众了解药物信息之用,不构成任何医疗建议、诊断或治疗方案。用药请遵医嘱并以官方说明书为准。 阅读完整免责声明